Teratogenicity of patulin and patulin adducts formed with cysteine
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چکیده
منابع مشابه
Teratogenicity of patulin and patulin adducts formed with cysteine.
The mean lethal dose of patulin for the chicken embryo injected in the air cell before incubation was determined to be 68.7 mug and that for the 4-day-old embryo was 2.35 mug. Both patulin (1 to 2 mug/egg) and the reaction mixture between patulin and cysteine (15 to 150 mug of patulin equivalents) were teratogenic to the chicken embryo. At least two ninhydrin-negative and four ninhydrin-positiv...
متن کاملCommentary: MRC Patulin trial.
The MRC Patulin trial1 was undertaken in 1943–1944 to investigate a proposed remedy for the common cold. Only a few clinical trials took place before the second world war and they often had serious defects of planning or execution. The Patulin trial, it is claimed, was the first to meet the rigorous requirements for a scientifically acceptable trial with concurrent controls, as set out original...
متن کاملBiosynthesis and Toxicological Effects of Patulin
Patulin is a toxic chemical contaminant produced by several species of mold, especially within Aspergillus, Penicillium and Byssochlamys. It is the most common mycotoxin found in apples and apple-derived products such as juice, cider, compotes and other food intended for young children. Exposure to this mycotoxin is associated with immunological, neurological and gastrointestinal outcomes. Asse...
متن کاملPatulin-induced suicidal erythrocyte death.
BACKGROUND Patulin, the most common mycotoxin in apples and apple-derived products, triggers apoptosis and has thus been considered for the treatment of cancer. Similar to apoptosis of nucleated cells, erythrocytes may enter suicidal death or eryptosis, which is characterized by cell shrinkage and by cell membrane scrambling leading to phosphatidylserine-exposure at the erythrocyte surface. Sti...
متن کاملProduction of patulin by Penicillium expansum.
Twenty-seven isolates of Penicillium expansum Lk. ex Thom obtained from Europe, Australia, and North America from seven different fruit hosts all produced patulin in culture. Six isolates were essentially nonpathogenic in apple fruits. In culture, patulin generally accumulated to much higher levels than in apple fruits. At all temperatures permitting fungus growth, patulin was produced. However...
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ژورنال
عنوان ژورنال: Applied and Environmental Microbiology
سال: 1976
ISSN: 0099-2240,1098-5336
DOI: 10.1128/aem.31.5.664-667.1976